Mouse over the terms for more detail; many indicate links which you can click for dedicated pages about the topic. Data table showing topics related to specific cancers and associated disorders. Scope includes mutations and abnormal protein expression. Note: list is not exhaustive. Number of papers are based on searches of PubMed click on topic title for arbitrary criteria used. Summary of gene and mutations by cancer type from ICGC.
GeneSearch Breast Lymph Node Assay
GeneSearch™ Breast Lymph Node (BLN) Assay Post Approval Study
View Full Version. Table of Contents. Page Thursday, 25 March Poster Sessions. SLN positivity.
Page 162 - EBCC7_abstractbook
Diagnostics guidance [DG8] Published date: August CK19 is normally not present in healthy lymph node tissue. The system does not need the mRNA to be extracted from the tissue and purified before analysis. Since the metastatic foci may not be evenly distributed throughout the node, the system provides more accurate results if more of the node is analysed because there is less risk of tissue allocation bias sample bias. Tissue allocation bias can occur when half of the lymph node is analysed using an intraoperative test and the other half using histopathology, if the metastasis is only contained in the tissue slices used for one of the methods.
A new test that examines large sections of the sentinel lymph node for genes expressed by breast cancer could reduce the risk of recurrence and multiple surgeries, doctors say. The sample represents more than 10 times the amount of tissue examined in traditional biopsies. And because the test examines the tissue with molecular tools, it is more sensitive, says Dr. Done during a lumpectomy, the GeneSearch test uses molecular diagnostic methods to examine more tissue than traditional sentinel node biopsies, reducing the chance of false negative results, says Stephen Peiper, chair of the MCG Department of Pathology and Georgia Cancer Coalition Distinguished Cancer Clinician and Scientist. The sentinel node, located in the armpit, filters fluid from the breast.